Cyproterone acetate/ethinyl estradiol for acne and hirsutism: time to revise prescribing policy

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منابع مشابه

Cyproterone acetate/ethinyl estradiol for acne and hirsutism: time to revise prescribing policy.

Clinical manifestations of androgen excess-hirsutism, acne and alopecia-are very common and distressing symptoms in women of reproductive age. These symptoms are frequently associated with polycystic ovary syndrome, in which condition menstrual disturbances are also common. The combination of the anti-androgen cyproterone acetate (2 mg) and ethinyl estradiol (35 microg) (co-cypridiol) is of pro...

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Flutamide versus a cyproterone acetate-ethinyl estradiol combination in moderate acne: a pilot randomized clinical trial

BACKGROUND The use of oral flutamide is rarely investigated in acne therapy. The aim of this study was to compare the efficacy of oral flutamide with that of a cyproterone-estradiol combination in treating acne lesions. METHODS A randomized clinical trial enrolled patients with moderate acne into two equal groups to receive either oral flutamide or the cyproterone-estradiol combination for 6 ...

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Comparison of Spironolactone plus Cyproterone Acetate plus Cyproterone Compound with Spironolactone plus Cyproterone Compound in Hirsutism: A randomized clinical trial

Background: Monotherapy is not usually effective in the treatment of hirsutism. Objective: Comparison of 2 therapeutic regimens in the treatment of hirsutism. Patients and methods: In this open parallel controlled clinical trial, 101 Patients suffering from hirsutism were randomly divided into two equal groups. 50 patients were treated with spironolactone (50 mg/day) plus cyproterone comp...

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albumin utilization in a teaching hospital in tehran: time to revise the prescribing strategies

background : since albumin imposes a relatively high cost to a healthcare system, drug use evaluation for this drug is much more important. this study wants to evaluate pattern of albumin use in a large university affiliated hospital in tehran, iran. methods : a concurrent, cross-sectional study was performed in “shaheed rajaei” cardiovascular, medical and research center. all inpatient adults ...

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More codeine fatalities after tonsillectomy in North American children. Time to revise prescribing practice!

In 2009 we reported the fatal case of a toddler who had received codeine after adenotonsillectomy for obstructive sleep apnea syndrome. The child was an ultra-rapid metabolizer of cytochrome P4502D6 (CYP2D6). We now report 3 additional fatal or life-threatening cases from North America. In the 2 fatal cases, functional gene duplications encoding for CYP2D6 caused a significantly greater product...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2007

ISSN: 0268-1161,1460-2350

DOI: 10.1093/humrep/dem379